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Carvacrol

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Carvacrol

Oregano (Origanum vulgare) is a flowering plant from the mint family (Lamiaceae). It is native to the temperate regions of western and southwestern Eurasia and the Mediterranean region. Oregano contains two powerful compounds called carvacrol and thymol, which have antibacterial and antifungal properties. Also, this medicinal plant benefits from antioxidant, anti-inflammatory, antimicrobial, anti-flatulent, diuretic, expectorant and expectorant properties.

This plant can be used to treat colds, relieve nasal congestion, strengthen the body’s immune system, relieve menstrual cramps, improve heart health, reduce adrenal fatigue, and fight toothache. Oregano is also effective in preventing and treating high blood sugar. The increase of antibiotic-resistant bacteria has increased the interest in natural compounds as alternative antimicrobial agents to control pathogenic microorganisms. Plant essential oils are attractive alternatives to antibiotics because they are natural, have no residues, and are difficult to induce resistance to.

Among them, carvacrol-rich essential oils (such as oregano essential oil) have been widely used as natural antibiotics in Europe and the United States due to their high antibacterial activity and antiseptic effects. Carvacrol is a phenolic monoterpene that is present in a high percentage of oregano essential oil (Origanum vulgare). Carvacrol has a wide spectrum of biological activities, which has significant potential for clinical applications such as antimicrobial, antioxidant and anticancer activities. Antimicrobial activity of carvacrol is higher than other volatile compounds in essential oils due to the presence of free hydroxyl group, hydrophobicity and its phenol part.

Carvacrol has a high inhibitory effect against both Gram-positive and Gram-negative bacteria groups. Carvacrol is very effective against Escherichia coli, Salmonella and Bacillus cereus pathogens. The antibacterial effect of carvacrol, which is stronger against gram-positive bacteria than gram-negative bacteria, is mainly based on damage to the bacterial membrane. By increasing the permeability and depolarization of the cytoplasmic membrane, carvacrol leads to the dissolution of the proton motive force and then to a decrease in ATP synthesis, which leads to a decrease in other energy-dependent cellular processes, including the synthesis of enzymes and toxins (Nostro and Papalia, 2012). ).

The non-biocidal concentration of carvacrol disrupts the natural growth of biofilm, preventing the formation of protein mass and stopping at the microcolony stage. The antimicrobial ability of carvacrol and its synergistic effects in combination with a number of antibiotics, including macrolides, have been reported (Langeveld et al., 2014). In the study of the antibacterial activity of different essential oils, it has been shown that carvacrol alone or in combination with erythromycin works well against erythromycin-resistant group A streptococcus (GAS) and can potentially be recognized as a new treatment tool (Magi et al., 2015). . Carvacrol is also very effective against various fungi.

Carvacrol has broad fungicidal activity without side effects even against fluconazole resistant strains. The effectiveness of carvacrol in the prevention and treatment of vaginal candidiasis has been confirmed in the laboratory (Chami et al., 2004).

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